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中文摘要：
采用超临界流体增强溶液分散度法，对制备阿莫西林-乙基纤维素-卡波谱缓释微囊进行了初步研究，探索了制备微米级缓释药物微囊的新方法。在对制备乙基纤维索空白微粒影响因素研究的基础上，选择了较为适合的工艺参数：CO2流速0-42m／s，温度40℃，压力9．0或12．0MPa。在2种压力下分别得到平均粒径为5．48μm和2.85μm的药物微囊，其载药量为9．53％和9．70％，同时还考察了制得微囊药物的释放度曲线，结果表明阿莫西林微囊具有明显的缓释效果。超临界流体增强溶液分散度法是制备微米级药物微囊的极有前途的方法。
英文摘要：
The characteristics of sustained-releasing amoxicllin-ethylcellulose-carbopol microcapsules, prepared by the Solution Enhanced Dispersion by Supercritical fluids （SEDS） process, were studied. A new method for pharmaceutical microcapsule preparation was investigated. Based on the investigation of the microparticle formation of ethylcellulose, the suitable experimental parameters of microcapsule formation such as velocity of CO2 （0.42 m/ s）, temperature （40℃） and pressures （9 and 12 MPa） were selected. Under the different pressures, the microcapsules＇ diameters are 5.48 μm and 2.85 μm, and the contents of drug are 9.53% and 9.70% respectively. And the drug releases were also measured. The results of the experiment indicate that the microeapsules have the sustained-release properties; the SEDS process is a promising method to prepare microcapsules of drugs.
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