中文摘要：

以全氟化碳（Perfluorocarbons,PFC）为通气媒介的部分液体通气技术是近年来新兴的治疗ALI/ARDS的技术,其中对促炎因子的抑制作用可能是保护机制之一。虽然目前有关PFC抗炎的分子机制尚未完全阐明,但细胞和动物实验充分证明了PFC可以拮抗ALI/ARDS的炎症反应,可临床研究却令人失望。本研究就近年来全氟化碳对促炎因子TNF-α、IL-1、IL-6、IL-8影响的相关研究进展进行综述。

英文摘要：

Perfluorocarbones （PFC）-based partial liquid ventilation （PLV） is of interest for the treatment of acute lung injury/acute respiratory distress syndrome （ALI/ARDS）. Cellular and animal studies have revealed that PFC suppresses anti-inflanunatory response, which may contribute to the protective mechanisms in ALI/ARDS. But clinical trials did not show a satisfactory outcome of PLV in ALI/ARDS patients. This article reviews the effects of PFC on decrease of pro-inflammatory cytokines TNF-α, IL-1, IL-6 and IL-8 in treatment of ALI/ARDS.