中文摘要：

在药抵抗和转移考察白血病干细胞(最低有效字符)的中央角色的目的，试图对 leukemia.Data 的恶化提供关键卓见进引起白血病的病理和发展中的新奇治疗学的策略采购在这评论使用的数据主要从用关键学期在 PubMed 报导的研究被获得“开始肿瘤的房间”，“白血病干细胞”，“药抵抗”和“转移” .Study 选择白血病干细胞 wer 的研究上的相关文章这评论总结了最低有效字符的起源，特征，隔离和鉴定。它由说明可能的机制和目的提供新奇治疗学的策略因为指向最低有效字符的 treatment.Conclusion 最低有效字符在试验性的模型和临床的实践在药抵抗和白血病和新有希望的指向最低有效字符的治疗保证调查的转移起一个关键作用在药抵抗和白血病的转移加亮最低有效字符的关键角色。

英文摘要：

Objective To review the central role of leukemia stem cells （LSCs） in drug resistance and metastasis, aiming to provide key insights into leukemogenic pathology and developing novel therapeutic strategies against the relapse of leukemia.Data sources The data used in this review were obtained mainly from the studies reported in PubMed using the key terms ＂tumor-initiating cells＂, ＂leukemia stem cells＂, ＂drug resistance＂ and ＂metastasis＂.Study selection Relevant articles on studies of leukemia stem cells were selected.Results Increasing numbers of studies have suggested the importance of cancer stem cells （CSCs） in the initiation and maintenance of cancer, especially in leukemia. This review has summarized the origin, characteristics, isolation and identification of LSCs. It highlights the crucial role of LSCs in drug resistance and metastasis of leukemia by illustrating possible mechanisms and aims to provide novel therapeutic strategies for LSCs-targeted treatment.Conclusion LSCs play a crucial role in drug resistance and metastasis of leukemia and new promising LSCs-targeted therapies warrant investigation in both experimental models and clinical practice.