中文摘要：

合适的支架是进行组织工程研究必需的条件之一．作者运用实验室自行研制的可控电纺丝系统，对具有良好生物相容性的明胶和生物可降解并具有良好成纤性能的聚己内酯（PCL）的复合电纺丝纤维的制备及影响因素进行了详细的探讨．实验结果表明：明胶在与PCL混合的情况下成纤能力得到较大提高，并分别制得了直径介于250~660nm、均匀无珠状物的多孔纤维膜．由于明胶具有良好的生物和组织相容性，PCL和明胶的混合不仅明显提高了二者的成纤能力，改变了各自都不容易被电纺的缺陷，更重要的是这二者的复合纤维兼具天然高分子和合成聚合物的优点，将为进一步对食道和血管组织工程的研究提供合适的支架样品和技术服务，对组织工程领域的研究起到促进作用．

英文摘要：

Fabrication of appropriate scaffold is a key issue for tissue engineering research. In this paper, a software controlled electrospinning system currently in use is introduced. The system parameters such as polymer solution properties （viscosity and concentration）, and process parameters such as electric potential, solution flow rate, distance between the nozzle and collection screen, and ambient parameters are studied in a detail manner. Under conditions of optimal operation, uniform composite fibers of gelatin and polycaprolactone are fabricated with diameters ranging from around 250 to 660 nanometers. The composite fiber sheet produced from the proposed system features in good biocompatibility and mechanical properties from gelatin and polycaprolactone.