中文摘要：

细胞自噬是普遍存在于真核细胞中的细胞生物学行为,其主要作用是清除或降解细胞内受损伤的细胞结构、衰老的细胞器以及不再需要的生物大分子等,同时也为细胞内细胞器的构建或细胞结构的再循环提供原料。自噬作用在生物体生长发育、细胞分化及对环境应激的应答方面极为关键。在胞内感染细菌和病毒感染宿主细胞的过程中,自噬一方面能促进感染细胞对病原体的清除,另一方面,胞内感染病原体通过某些机制逃避细胞的自噬作用,与胞内感染的致病机制有关。作者对近期关于胞内感染的病原体与细胞自噬的相互作用的研究作一综述。

英文摘要：

Autophagy is a common biological phenomenon in eukaryotic cells.The main function of autophagy is eliminating the injured cellular composition,aged cellular organs,giant molecule,and degradation of a cell′s own components.In the mean time autophagy provide materials for the construction of intracellular organs,which is called recycling of cellular composition.Autophagy plays an essential role in cell growth,differentiation and environmental stress.Autophagy enhance the eliminating of the intracellular pathogen,on the other hand the intracellular pathogens escape the autophagy.The interaction between them is related to the pathological mechanisms.This review mainly focuses on the current research of the mechanism of interaction between intracellular pathogen and autophagy.