中文摘要：

目的建立罗通定缓释片体外释放度测定方法，评价其体外释药行为。方法用紫外分光光度法和体外释放度试验，考察罗通定缓释片在不同释放介质中和不同释放时间的累积释放度。结果罗通定在281nm处有最大吸收，在5～250μg／ml内与吸收度呈良好的线性关系：Y=0．0143X＋0．0378，r=0．9999。罗通定缓释片在人工胃液中的体外释药行为理想，符合Higuchi方程：Mt／M∞=0．3933t^1/2-0．2274，r=0．9992。结论本法简便、快速，适用于罗通定缓释片的质量控制。

英文摘要：

Objective To establish a UV method to determine the release degree of rotundine sustained-release tablets and to evaluate its in-vitro release behavior. Methods Ultraviolet speetrophotometry was applied to determine the release degree of rotundine sustained-release tablets with different release mediums. Results Rotundine had the highest absorptive peak at 281 nm mavelenth and a good linearity in the range of 5 - 250μg/ml （ Y = 0. 0143X ＋ 0. 0378, r = 0.9999）. Rotundine sustained-release tablets had a good release behavior in gastric juice, which fits the Higuchi Square ： Mt/M∞ = 0. 3933t^1/2 - 0.2274, r = 0. 9992. Conclusion This method is simple, rapid, and can be used for the quality control of rotundine sustained-release tablets.