中文摘要：

采用过氧化氢/蒸馏水（H2O2/H2O）溶液结晶体为模板,通过冷冻干燥法及发泡技术制备了含有层状孔及球形孔两种孔型的羟基磷灰石（HA）支架.通过改变浆料中H2O2的含量来控制多孔陶瓷支架形貌,并对其生物性能进行分析.结果表明：当为纯水浆料时,多孔陶瓷平均片层间距为250～580 μm;当H2O2 /H2O中H2O2的含量为3％（体积分数,下同）时,多孔陶瓷中出现球形孔,球形孔径为180～410 μm;当H2O2的含量增大至9％时,球形孔孔径可达300～1 000 μm; H2O2含量为6％时多孔HA陶瓷支架的开孔孔隙率最大.体外模拟实验表明,球形孔及层状孔两种孔形HA陶瓷支架材料有利于细胞生长,材料表面细胞结构清晰,铺展形态良好.支架强度值符合骨组织工程中细胞支架材料的压缩强度要求.

英文摘要：

The hydroxyapatite （HA） porous bioceramic scaffolds containing both the lamellar macrospores and spherical macrospores were fabricated by a freeze casting with peroxide hydrogen and deionized water （H2O2/H2O solution） as the pore forming agent.The influence of the volume content of peroxide in mixed solvent on the structure and properties of the HA scaffolds was investigated.The results show that the average lamellar spacing is 250-580μm in the aqueous slurry.When the volume fraction of H2O2 in H2O2/H2O is 3％,the spherical macrospores appear in the porous ceramic,and the pore size range of the spherical macrospores is 180-410μm.When the volume fraction of H2O2 in H2O2/H2O is increased to 9 ％,the pore size of the spherical macrospores is increased to 300-1 000μm.The open porosity of the HA scaffold is a maximum value with 6％ H2O2.The vitro cellular assay indicates that the HA porous scaffolds support the structure of the spherical macrospores and lamellar macrospores conducive to cell growth and clear cell surface structure.The compressive strength of the scaffold obtained can meet the requirement of bone tissue engineering.