中文摘要：

骨关节炎（OA）的临床诊断尚缺乏有效的生物学标志物。研究证实标志物Ⅱ型胶原羧基端交联肽（CTX-Ⅱ）是关节软骨降解的特异性指标。CTX-Ⅱ检测可及时反映软骨损伤和退变程度、诊断OA发生、预测OA进展和监测药物治疗效果，从而间接反映OA患者的病情。CTX-Ⅱ的应用主要集中于OA早期，并需联合其他生物学标志物一起检测，以便更准确的反映OA病变，但其检测结果具体临床指导意义还需进一步完善。

英文摘要：

Effective biomarkers for clinical usage of osteoarthritis are still limited. It was confirmed that C-terminal crosslinking telopeptide of type Ⅱ collagen （CTX-Ⅱ ） was a specific marker reflecting degradation of articular cartilage. Detec- tion of CTX- Ⅱcould promptly ref/ect level of cartilage injury and degradation, diagnose OA, predict its progress, monitor effects of drug treatment, thus, reflect the condition of osteoarthritis patient indirectly. Application of CTX-Ⅱ focused mainly on in the early stage of OA and need together to detect with other biomarkers,in order to more accurately reflection of the patho- logical changes of OA,but the specific clinical significance of CTX-Ⅱ results still need to improve further.