中文摘要：

动脉粥样硬化（atherosclerosis，AS）性血管病变是导致2型糖尿病患者致残、致死的主要原因之一。最终大部分糖尿病患者死于As相关并发症。胰岛素分泌不足和胰岛素抵抗是2型糖尿病的主要病理生理特征。胰岛素受体广泛分布于全身各个器官和组织，胰岛素受体信号通路的激活对维持细胞正常生理功能有重要的作用。

英文摘要：

Atherosclerotic vascular lesion is one of the most important causes for disability and mortality in diabetic patients. Eventually, the majority of patients with diabetes die from complications related to atherosderosis. Lack of insulin secretion and insulin resistance are the main pathogenesis for Type 2 diabetes. Insulin receptor is widely expressed in various organs and tissues. Activation of the insulin signaling plays a key role in maintaining the normal physiological function of ceils.