Chiral 包含氮的杯[4 ] arene 被 25,27-di (2-bromoethoxy ) 的反应容易综合有 S- 的 -26,28-dihydroxy-5,11,17,23-tetrakis(t-butyl)calix[4]arene (在优秀产量的(?)-1-phenylethylamine,和认出 mandelic 酸和 2,3-dibenzoyltartaric 酸的 enantiomers 的显示出的好能力。这发现有潜在的申请到羧基的酸的 enantiomers 的试金和分离。
Chiral nitrogen-containing calix[4]arene was easily synthesized by the reaction of 25,27-di(2-bromoethoxy)- 26,28-dihydroxy-5,11,17,23-tetrakis(t-butyl)calix[4]arene with S-(-)-1-phenylethylamine in excellent yield, and showed good ability to recognize the enantiomers of mandelic acid and 2,3-dibenzoyltartaric acid. This finding has potential application to assay and separation of enantiomers of the carboxylic acids.