中文摘要：

目的深入分析AKR／J小鼠的与胆固醇代谢相关的表型特征及其内在联系，探讨其作为人类疾病模型的价值。方法AKR／J小鼠为实验组，BABL／C小鼠为对照组，取两组小鼠毛发镜下观察；取两组小鼠的肾上腺、卵巢、睾丸，冷冻切片后进行油红O染色；检测并比较两组小鼠肾上腺相关激素（皮质素、醛固酮、ACTH）水平；检测并比较血常规、血糖、血脂（甘油三酯，总胆固醇）、血电解质及血压。结果AKR／J小鼠内部毛发结构排列紊乱，肾上腺脂类含量明显少于对照鼠，皮质素、醛固酮、总胆固醇浓度比对照小鼠有显著性降低（P〈0．01）；血液Na＋、Cl-、Mg^2＋浓度及平均血红蛋白含量低于对照鼠，Ca^2＋浓度高于对照鼠（P〈0．05），其他各项指标均无显著性差别。结论AKR／J小鼠是人类毛发结构缺陷、肾上腺皮质机能减退等疾病的天然模型，也是胆结石及动脉粥样硬化的抗性模型。

英文摘要：

AKR/J mice have several significant strain characteristics. This paper made an in-depth analysis on the phenotype characteristics of AKR/J mice, and evaluated their applications as human disease models, such as cholesterol metabolism-related diseases. Methods：AKR/J and BAB1/C mice were set as the experiment group and the control group. The hair of mice was observed under microscopy directly; The tissues of adrenal glands, ovaries and testes were dissected for oil red 0 stain after being frozen and sliced; The adrenal gland-related cortical hormones, such as the cortine, aldosterone and ACTH, were measured; Meanwhile, blood routine examination items such as blood glucose, blood lipids （triglyceride and total cholesterol） , blood electrolytes and blood pressure were examined. Result： Adrenocortical lipid depletion and interior hair derangement were verified in AKR/J mice. Compared with the control, the concentration of cortine, aldosterone, total cholesterol in AKR/J mice were significantly decreased （P 〈 0.01 ）. The concentration of blood Na ＋ ,Cl- ,Mg^2＋ and the average hemoglobin content were lower than those of control mice （p 〈 0.05） ; Other items were no significant difference between the AKR/J mice and the control mice. Conclusion： The AKR/J mice are ideal animal models for human diseases researches such as hair structure defect, adrenal hypofunction, gall-stone and atherosclerosis.