中文摘要：

目的：研究骨肉瘤中HER2基因表迭与骨肉瘤患者发生肺转移的关系。方法：对43例骨肉瘤患者的临床病理资料进行回顾性研究，应用HER2单克隆抗体对组织切片进行免疫组织化学染色，并将上述资料与随访患者发生肺转移情况进行统计学分析。结果：骨肉瘤患者HER2表达与患者发生肺转移相关（P〈0．05），HER2高表达的骨肉瘤患者发生肺转移的可能性大。结论：HER2检测是判断骨肉瘤发生肺转移的一项有价值的指标；同时，HER2基因为骨肉瘤的生物治疗提供一种可能的靶点。

英文摘要：

Objective To evaluate whether the human epidermal growth factor receptor 2（HER2） expression in ostcosarcoma patients predicts the risk of pulmonary metastases. Methods The clinicopathologie information of forty-three eases with osteosarcoma was studied retrospectively. By using anti-HER2 monoclonal antibody, the expression of HER2 was assessed by standard immunohistochemical staining respectively. The above data, together with the follow-up data of the pulmonary metastasis of patients were analyzed statistically. Results The expression of HER2 was correlated with the patients＇ lung metastasis（ P 〈0. 05）; The HER2 overexpression in osteosarcoma increased the risk of lung metastasis. Conclusions HEP,2 expression is a useful prognostic indicator in osteosarcoma. The correlation also suggests HER2 should be considered as a possible target for the treatment of osteosarcoma.