中文摘要：

糖尿病肾病已成为全球终末期肾病的最主要病因之一。严格控制血糖可以有效减少糖尿病肾病发生及疾病进展；然而随着肾功能减退，会出现体内降糖药物蓄积，增加药物毒副反应及低血糖事件，所以糖尿病肾病患者如何有效且安全的使用口服降糖药物至关重要。本文主要讨论各类口服降糖药物包括胰岛素促泌剂、非胰岛素促泌剂及新型口服降糖药物在糖尿病肾病中的应用。

英文摘要：

Diabetic nephropathy （DN ） is one of the most common causes for end-stage renal disease （ESRD ） in the world.Intensive glucose control is effective in decreasing the incidence and progression of DN.As the renal function reduces,accumulation of hypoglycemic drugs can occur in the patients,which increases adverse reactions of the drugs as well as hypoglycemia events.This article mainly discussed the application of oral hypoglycemic drugs used for DN,including insulin secretagogues,non-insulin secretagogues,and other new type of oral hypoglycemic drugs.