中文摘要：

目的：探讨自身免疫性甲状腺疾病（AITD）中辅助性T淋巴细胞（Th1/Th2）的平衡偏移及其在发病中的作用。方法：选择21例初发Graves病（GD组），21例桥本甲状腺炎（HT组）和45名健康人（对照组）为研究对象，应用流式细胞仪技术检测外周血淋巴细胞中CD4^＋CCR5^＋和CD4^＋CD30^＋细胞，以其各自百分比和平均荧光强度（MFI）作为反映，Th1/Th2免疫应答强度的指标。结果：与对照组相比，GD组CD4^＋CD30^＋细胞升高（P〈0、05），而CCR5^＋细胞MFI明显减低（P〈0、01）；HT组CD4^＋CCR5^＋和CD4^＋CD30^＋细胞均升高（P〈0、05）。GD组中CD30^＋细胞MFI与TRAb浓度正相关，与FY3、FY4、TSH均无相关性。结论：GD的发生可能与Th2优势应答密切相关：Th1和Th2细胞可能共同拳与了HT的发病。

英文摘要：

Objective： To explore the T helper cells （Th1/Th2） bias in autoimmtme thyroid disease （AITD） and its effect on the development of AITD. Methods： The percentage and mean fluorescence intensity （MFI） of CCRS-posifive and CD30-positive cells were determined by using flow cytometry in 21 patients with Graves＇ disease （GD group）,21 patients with Hashimoto thyroiditis （HT group）,and 45 healthy subjects （control group）. Results： Compared with the control group, the percentage of CD30-positive cells significantly increased （P 〈 0.05） and the MFI of CCR5-positive cells significantly decreased （P 〈 0.01 ） in GD group. The percentages of both CCR5-positive and CD30- positive cells significantly increased in HT group （P 〈 0.05）. The MFI of CD30-positive cells were positively correlated with the level of thyroid stimulating hormone receptor antibody. Condusion： GD is a Th2-dominated disease. Both Thl and Th2 cells may be involved in the pathogenesis of HT.