中文摘要：

目的：探讨新生隐球菌不同变种在原发性小鼠新生隐球菌皮肤感染中的作用。方法：按照我们建立的原发性皮肤隐球菌感染模型的方法，将新生隐球菌新生变种标准野生株B3501与格特变种标准株ATCC32609分别皮内接种于免疫抑制与非抑制的BALB／c小鼠，皮损真菌培养与组织病理检查确证感染。观察2种隐球菌感染的病程，比较皮损形成与消退的平均时间。结果：2种变种的新生隐球菌皮下接种于BALB／c小鼠后，可以在免疫抑制与非抑制的BALB／c小鼠皮肤上产生丘疹、结节、溃疡、传染性软疣样皮损，皮损可以自愈，真菌培养与病理确证为隐球菌感染。2种菌株只在免疫正常小鼠的皮损形成时间上存在差异。结论：新生变种与格特变种的新生隐球菌均可以造成BALB／c小鼠相似的皮肤感染。推测2种变种对原发性皮肤感染的致病力可能无差异，新生变种发病较多可能与其分布有关。

英文摘要：

Objective： To investigate the role of different variety of Cryptococcus neoformans in mice cutaneous infection. Methods： C. neoformans varities neoformans, B3501, and C. neoformans varities gattii, ATCC 32609, were intradermaly inoculated into immunocompetent and immunocompromised BALB/c mice, respectively. Mycological and histopathologic tests were used to confirm the infection and the course was compared among the groups. Results： Different manifestation of the skin lesions, such as nodule, papule, ulcer and lesions mimicking mollnscum contagiosum occurred almost in the same manner by the 2 strains of C. neoformans in the two kinds of BALB/c mice. Only the mean time of lesion formation was different in the immunocompetent mice inoculated by the 2 strains of C. neoformans. Conclusion：Both varieties of C. neoformans can cause primary mice skin infection in the same manner. We suppose that there is no difference between the 2 varieties of C. neoformans in the mice skin infection.