本文利用牛血清白蛋白(BSA)作为表面活性剂,在水相中成功合成了具有复合结构的Ag2Se-Se纳米粒子。该复合纳米粒子具有较好的分散性。整个实验过程均在室温下进行,合成方法简单、可控且重复性好。结合傅立叶变换红外光谱(FTIR)和紫外吸收光谱(UV-vis)的结果,分析了纳米粒子复合结构的形成过程;采用高分辨透射电子显微镜(HRTEM)结合选区电子衍射(SAED)和能谱分析(EDS),对制备的复合粒子形貌和成份组成进行了分析测定;利用X射线粉末衍射(XRD)分析了复合粒子的晶体结构和相组成。采用BSA修饰制备得到的纳米粒子生物相容性好,可以在生物医学领域中得到广泛应用。
Well-dispersed Ag_2Se-Se composite nanoparticles were synthesized by using bovine serum albumin(BSA) as surfactant at room temperature in an aqueous solution.The facile method was controllable and reproducible.A possible mechanism to interpret the formation of Ag_2Se-Se nanoparticles was proposed based on the UV-vis spectroscopy and flourier transformation infrared(FTIR) spectroscopy measurements.The nanostructure of the composite was characterized by high-resolution transmission electron microscopy(HRTEM),selected-area electron diffraction(SAED) and energy dispersive spectroscopy(EDS) to obtain the information about morphology and chemical composition.Powder X-ray diffractometry(XRD) was employed to determine crystalline structure and phase components.In addition,biocompatibility of the composite nanoparticles modified by BSA is improved,which leads to promising applications of these nanomaterials in biomedical engineering.