中文摘要：

目的通过观测额尔敦—乌日勒对动脉粥样硬化家兔血管内皮因子内皮素（endothelin,ET）、血小板活化因子（platelet activating factor,PAF）的影响,明确其稳定斑块的作用机制。方法将50只家兔,随机分为正常组和造模组。正常组10只不进行造模,普通饲料喂养;造模组40只采用高脂饮食喂养、免疫损伤、球囊拉伤术复合因素造模,建立家兔动脉粥样硬化易损斑块模型。8周造模成功后,将最终造模成功的29只家兔随机分为模型组（n=10）、额尔敦—乌日勒组（n=10）、辛伐他汀组（n=9）,额尔敦—乌日勒组和辛伐他汀组分别给予额尔敦—乌日勒、辛伐他汀进行干预,24周后取材,运用酶联免疫吸附法和免疫组化方法检测各组家兔血管内皮因子PAF和ET的浓度及表达情况。结果与模型组比较,额尔敦—乌日勒显著降低血清ET、PAF（P〈0.01）,在降低ET水平上优于辛伐他汀组;与模型组比较,额尔敦—乌日勒组能降低主动脉ET、PAF表达（P〈0.01）,在降低ET表达上优于辛伐他汀组（P〈0.05）。结论额尔敦—乌日勒具有改善动脉粥样硬化血管内皮功能的作用。

英文摘要：

Objective To explore the effects and possible mechanisms of Eerdun-wurili in stabilizing the vulnerable plaques using a rabbit model of AS vulnerable plaque. Methods We take 50 male New Zealand white rabbit which were underwent balloon-induced abdominal aortic wall injury and were fed a high cholesterol diet for 8 weeks to establish rabbit atherosclerosis model vulnerable plaques; Rabbits were then randomly divided into three groups： the normal group（ n = 10; General diet without any model）;the model group（ n = 10; without any treatment）; the Eerdun-wurili group（ n = 10; using Eerdun-wurili for treat） and the simvastatin group（ n = 10; using simvastatin for treat）. 24 weeks later,the rabbits were sacrificed to observe concentrations and expressions of ET; PAF expressions were measured by means of Enzyme-linked-immunosorbent assay（ ELISA） and immunohistochemistry. Results Elisa test results showed that Eerdun-wurili can significantly reduce the levels of ET and PAF（P〈0. 01）; Rabbit aortic immunohistochemistry results showed： compared to the model group,ET and PAF expressions in the Eerdun-wurili group were significantly reduced（P〈0. 01）; and the ET expression is significantly less than the simvasta-tin group（P〈0. 05）. Conclusion Eerdun-wurili may though reducing the levels of Endothelial Factor ET and PAF to play the role of anti-AS vulnerable plaques.