中文摘要：

背景：口腔黏膜组织工程期待能解决自体黏膜修复组织来源不足的难题。目的：综述组织工程化口腔黏膜的种子细胞的来源及选择、各种常见支架材料的优缺点及相关生长因子的研究进展。方法：由第一作者以＂tissue engineering of oral mucosa, seed cells, scaffold material, growth factor＂为检索词,检索PubMed 数据库及Elsevier数据库2000-01/2011-12有关文章。结果与结论：几种常见的口腔黏膜组织工程种子细胞在研究中都有较好的增殖或分化能力,脂肪干细胞与其他种子细胞相比具有更明显的优势,可作为一种较理想的种子细胞;各种常见的支架材料都有各自的优缺点,可以采用多种方式改善其性能;将一些关键的细胞因子运用到口腔黏膜组织工程中,能促进移植物血管化,加快伤口愈合过程。口腔黏膜组织工程将是在临床上能解决异体移植免疫排斥及传播疾病和自体黏膜修复组织来源不足等问题一种安全有效的修复方法。

英文摘要：

BACKGROUND： Tissue engineering of oral mucosa has been developed rapidly in the recent decades, looking forward to overcome increasing requirement of oral mucosa reconstruction and supply shortage. OBJECTIVE： To review the critical process of origin and choice of seed cells, scaffold materials and their advantages or disadvantages, and related growth factors in tissue engineered oral mucosa construction. METHODS： Databases of PubMed and Elsevier were retrieved by the first author to research the papers published 2000-01/2011-12 by using ＂tissue engineering of oral mucosa, seed cells, scaffold material, growth factor＂ as Keywords. RESULTS AND CONCLUSION： Several familiar seed cells of oral mucosa tissue engineering have good proliferation or differentiation capacity. Adipose-derived stem cells, which have more advantages compared to other seed cells, can be a kind of ideal seed cells. Multifarious common scaffold materials have their own advantages and disadvantages, and various methods can be applied to improve their properties. Application of some critical cytokines in oral mucosa tissue engineering can promote angiogenesis of implants and accelerate wound healing. Tissue engineering of oral mucosa is a safe and effective repairing method which can solve immunologic rejection and disease transmission of allograft and insufficient supply of autologous oral mucosa graft, and needs to be further researched.