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姜黄素及其类似物对自由基诱导的红细胞溶血的抑制作用
  • ISSN号：0253-2786
  • 期刊名称：《有机化学》
  • 时间：0
  • 分类：O62[理学—有机化学;理学—化学]
  • 作者机构：[1]兰州大学功能有机分子化学国家重点实验室,兰州,730000 兰州大学功能有机分子化学国家重点实验室,兰州,730000 兰州大学功能有机分子化学国家重点实验室,兰州,730000 兰州大学功能有机分子化学国家重点实验室,兰州,730000 兰州大学功能有机分子化学国家重点实验室,兰州,730000
  • 相关基金：国家自然科学基金(Nos.20172025,20332030)资助项目.
作者： 陈巍峰[1], 邓水玲[1], 周波[1], 杨立[1], 刘中立[1]
中文摘要：

　　自由基诱导的细胞膜脂质过氧化和DNA氧化性损伤被认为与癌症、动脉硬化等疾病有关[1].姜黄素(1)是烹饪调味品中的一种黄色色素,具有抗癌、抗炎、抗氧化等多种药理作用[2].我们合成了一系列姜黄素及其类似物1～7,以自由基诱导的红细胞溶血为模型,研究了它们的抗氧化活性.发现这些化合物对以水溶性自由基引发剂AAPH诱导的红细胞溶血都有抑制作用(Figure 1),并且具有邻位酚羟基的化合物3和4比姜黄素和其他类似物具有更高的活性.这为抗氧化治疗药物的发展提供了有用的信息.……

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期刊信息
  • 《有机化学》
  • 中国科技核心期刊
  • 主管单位:
  • 主办单位:中国化学会 中国科学院上海有机化学研究所
  • 主编：陈庆云
  • 地址：上海市枫林路354号
  • 邮编：200032
  • 邮箱：bianji@mail.sioc.ac.cn
  • 电话：021-54925244
  • 国际标准刊号：ISSN：0253-2786
  • 国内统一刊号：ISSN：31-1321/O6
  • 邮发代号:4-285
  • 获奖情况:
  • 中国期刊方阵“双效”期刊
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,美国化学文摘（网络版）,荷兰文摘与引文数据库,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,中国北大核心期刊（2000版）
  • 被引量:14408