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Triphenylphosphine-catalyzed Michael addition of alcohols to acrylic compounds
  • 时间:0
  • 分类:O623.612[理学—有机化学;理学—化学]
  • 作者机构:[1]Centre of Green Chemistry, College of Chemistry, South China University of Technology, Guangzhou, Guangdong 510640, China
  • 相关基金:Project supported by the National Natural Science Foundation of China (Nos. 20625205, 20332030 and 20572027).
  • 相关项目:适于超临界二氧化碳的催化体系及其应用研究
中文摘要:

到丙烯酸的混合物的白酒的灵巧的催化 triphenylphosphine 的迈克尔增加被描述。反应面对 10 mol% PPh3 在 refluxing 温度在开的空中被执行。迈克尔增加浸透,到丙烯腈或 acrylates 的不饱和的白酒被检验了。反应与 5%79% 的孤立的收益给了 -alkoxy 衍生物。PPh3 比以前为类似的反应,和产品使用的那些 trialkylphosphines 更便宜、更稳定能容易经由蒸馏与反应混合被分开。

英文摘要:

A facile triphenylphosphine-catalyzed Michael addition of alcohols to acrylic compounds was described. The reaction was carried out in open air at refluxing temperature in the presence of 10 mol% PPh3. Michael addition of saturated and unsaturated alcohols to acrylonitrile or acrylates has been examined. The reaction gave β-alkoxy derivatives with isolated yields of 5%-79%. PPh3 is cheaper and more stable than those trialkylphosphines previously used for the similar reactions, and the products can be easily separated from the reaction mixture via distillation.

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