位置：成果数据库 > 期刊 > 期刊详情页
Artemin的研究进展
  • ISSN号：1009-3419
  • 期刊名称：《中国肺癌杂志》
  • 时间：0
  • 分类：R974[医药卫生—药品;医药卫生—药学]
  • 作者机构：[1]天津医科大学总医院,天津市肺癌研究所,天津市肺癌转移与肿瘤微环境重点实验室,天津300052
  • 相关基金：国家自然科学基金（No.81000950）资助
作者： 寻广苏（综述）[1], 郭峰杰（综述）[2], 李志刚（审校）[2], 周清华（审校）[2]
关键词： 非小细胞肺癌, 表皮生长因子受体, 酪氨酸激酶抑制剂:靶向治疗, Non small cell lung cancer, Epidermal growth factor receptor, Tyrosine kinase inhibitor, Targeted therapy
中文摘要：

肺癌是当今世界上对人类健康和生命威胁最大的恶性肿瘤，也是临床治疗疗效最差的恶性肿瘤。非小细胞肺癌（NSCLC）组织中常可检测到表皮生长因子受体（EGFR）的高表达，而EGFR与肿瘤血管生成、肿瘤细胞扩散及增殖有关，其突变可以增强NSCLC对酪氨酸激酶抑制剂（EGFR-TKIs）的敏感性。早期的以吉非替尼为代表的EGFR-TKIs借助于高敏感性用于治疗NSCLC患者效果均较为显著，一度成为治疗非小细胞肺癌的主要治疗药物。但经过长期的使用NSCLC患者对EGFR—TKIs药物产生了耐药性表现．病情出现复发甚至恶化的情况。因此，对于吉非替尼等EGFR—TKIs耐药性进行研究，以期通过靶向耐药性相关分子联合治疗NSCLC具有重要意义。本文对EGFR—TKIs耐药相关的分子靶点及针对该靶点的分子抑制剂治疗NSCLC的最新研究进展进行综述。

英文摘要：

Lung cancer is one of the most malignant tumors in the world, which is the biggest threat to human health and life. The expression of epidermal growth factor receptor was detected in non small cell lung cancer tissues, and EGFR was associated with tumor angiogenesis, tumor cell proliferation and proliferation, and the mutation could enhance the sensitivity of NSCLC to tyrosine kinase inhibitors. Early in the treatment of NSCLC patients with the help of the EGFR-TKIs with the help of Gao Min＇s sensibility is more remarkable, once became the treatment of non small cell lung cancer. But after a long period of use of EGFR-TKIs patients on the drug resistance of NSCLC, the disease has a relapse or even worse. Therefore, it is important to study the drug resistance of EGFR-TKIs in the combination of targeted drug resistance related molecules in order to study the drug resistance of NSCLC. In this article, we reviewed the latest research progress of EGFR-TKIs drug resistance related molecular targets and the molecular inhibitors of NSCLC.

同期刊论文项目
nm23基因逆转肺癌转移的分子机理和信号传导调节
期刊论文 86 会议论文 12 获奖 6 著作 4
nm23-H1调控microRNAs逆转肺癌转移表型的分子机制研究
期刊论文 7
同项目期刊论文
The plasmid of pLXNP-nm3-H1-EGFP the lung Cancer cell line L9981-nm23-H1
nm232H1 基因转染前后人高转移大细胞肺癌细胞株双向凝胶电泳图谱分析
利用Pyrobest DNA聚合酶一步法进行大片段基因的定点突变
Double mutant P96S/S120G of Nm23-H1 abrogates its NDPK activity and motility-suppressive ability
CpG island methylator phenotype involving tumor suppressor genes located on chromosome 3p in non-sma
Raf与肺癌的研究进展
Raf全长及氨基端、羧基端真核表达载体的构建和表达
Nm23-H1基因逆转人高转移大细胞肺癌细胞L9981转移表型的分子机制
Alteration in gene expression profile and biological behavior in human lung cancer cell line NL9980
Molecular Research on Prediction of Tunner Metastasis in Lung Cancer
The Molecular Mechanisms,Signal Regulation of nm23-H1 Gene on Reversion of Lung Cancer Invasion and
Molecular mechanisms and signal regulation of lung cancer invasion and metastasis
MAPK通路支架蛋白KSP的研究进展.
转移抑制基因nm23-H1 参与肺癌Ras信号传导机理研究
nm23-H1 基因转染对人高转移大细胞肺癌细胞株L9981 中β2catenin 表达的影响
人低大细胞肺癌细胞株ZQH-80
人高大细胞肺癌细胞株ZQH-81
人大细胞肺癌转基因细胞株ZQH-81-1
Germline 3p-Specific CpG Island Methylator Phenotype Confers an Increased Risk of Non-Small Cell Lun
利用定点突变技术构建突变nm23-H-1和EGFP融合基因
nm23-H1基因转染前后人大细胞肺癌细胞株抑制消减cDNA文库的构建
Nm23-H1绿色荧光蛋白融合基因真核表达载体的构建和表达
Ras激酶抑制子KSR定点突变、表达和鉴定
nm23-H1基因转染L9981肺癌细胞前后基因表达谱的变化
nm23-H1基因转染对人高转移大细胞肺癌细胞株生物学行为的影响及作用机理
nm23-H_1基因点突变对人高转移大细胞肺癌细胞株L9981的GSK-3β激酶活性的影响
The Molecular Mechanisms of Nm23-H1 on invasion and metastasis of human Cances
Monocyte chemetactic protein-1 promotes lung cancer-induced bone resorptive lesions in vivo
Rapid indentification of downstream metastatic-related genes associated with nm23-H1 in lung cancer.
PKC-α在不同转移潜能的人肺癌细胞株中的分布和激活转位变化
靶向抑制ERK1/2信号传导通路对人高转移大细胞肺癌细胞株L9981恶性表型的影响
非小细胞肺癌患组织中内皮抑素mRNA的转录表达及临床意义
The molecular mechanism of Nm23-H1 gene transfection on reversing invasion and metastasis phenotype
Transfection of nm23-H1 increased expression of -Catenin, E-Cadherin and TIMP-1 and decreased the ex
人大细胞肺癌转基因细胞株ZQH-81-2
人大细胞肺癌转基因细胞株ZQH-81-3
人大细胞肺癌转基因细胞株ZQH-81-4
人大细胞肺癌转基因细胞株ZQH-81-5
高效原核表达载体pbv220的改造与应用
利用单核苷酸多态性芯片全基因组检测人大细胞肺癌细胞株的杂合性缺失和拷贝数变异
Intracellular Glutathione content influence the sensitivity of methylseleninic acid in human high-me
人大细胞肺癌高低转移株差异表达基因消减cDNA文库的构建和初步筛选
应用活体内生物发光技术对人高转移大细胞肺癌细胞株l9981成瘤性和转移性研究
“睡美人”转座子及其在肿瘤研究中的应用
nm23-H1基因转染逆转人高转移大细胞肺癌恶性表型分子机制的实验研究
不同转移潜能人大细胞肺癌细胞株转移相关microRNAs的筛选研究
蛋白质组学及其在肺癌中的研究进展
非小细胞肺癌的新标记物DMP1
高低转移大细胞肺癌细胞株L9981和NL9980间甲基化差异基因的初步研究
nm23-H1基因转染前后人高转移大细胞肺癌细胞株的比较蛋白质组学研究
Vegfr2-luc转基因子代小鼠的鉴定
肺腺癌吉非替尼获得性耐药相关microRNAs的筛选鉴定
基于“分子分期”的局部晚期非小细胞肺癌“个体化外科治疗”的长期生存结果
CCR7上调MMP-9表达促进非小细胞肺癌转移
利用定点突变技术构建突变nm23-H1和EGFP融合基因
转移抑制基因nm23-H1参与肺癌Ras信号传导机理研究
mm23-H1基因点突变对人高转移大细胞肺癌细胞株L9981的GSK-3β激酶活性的影响
小鼠Ras激酶抑制剂（KSR）基因氨基端和羧基端真核表达载体的构建及其在293T细胞中的表达
蛋白激酶C抑制剂CalphostinC抑制人高转移大细胞肺癌细胞株侵袭和转移的实验研究
电视胸腔镜手术在非小细胞肺癌诊治中的应用
MethylseIeninic Acid on The Apoptosis Induction and Invasion Inhibition in Human High-Metastatic Large Cell Lung Cancer Cell Line L9981
Screening and Verifying of Metastasis-associated Genes of Human Lung Cancer Cell Lines with Different Metastatic Potential
The N-Terminal Kinase Suppressor of Ras （KSR1） Complex Exhibits Nucleoside Diphosphate Kinase （NDPK） Activity
Effects of Methylseleninic Acid on the Proliferation and Cell Cycle in Human High Metastatic Large Cell Lung Cancer Cell Line L9981 and Its Molecular Mechanism
Research on the Antitumor Effect of Plumbagin by Inhibiting IL-6/STAT3 Pathway in Large Cell Lung Cancer
The Difference of Gene Expression Profile in Human Large Cell Lung Cancer Cell Lines with Different Metastatic Potential
The Difference of the Copy Number Variation and Loss of Heterozygosity of Human Lung Large Cell Cancer Cell Line with Different Metastatic Potential
Methylseleninic Acid on Apoptosis and Signal Pathway in Human Lung Cancer Cell Line
The Effects of IntracelluIar Glutathione Content on the Sensitivity of Methylseleninic Acid to Human High-metastatic Large Cell Lung Cancer Cell Line L9981
Methylation Profile Difference in Human High- Metastatic Large Cell Lung Cancer Cell Lines with Different Metastatic Potential
Comparative Proteomics Study on Human Highmetastatic Large Cell Lung Cancer Cell Lines Before and After Transfecting with Nm23-H1 Gene
Lung Cancer Metastatic Related Genes by Suppression Subtractive Hybridization
Noninvasive Assessment of Using Bioluminescent Imaging（BLI） to Research Methylseleninic Acid＂ Effect on the Growth And Spontaneous Metastasis in Human High-Metastatic Large Cell Lung Cancer Cell Line L9981
The Study on the Function of BAG-1 Gene and its Related Signaling Pathway in Human Lung Cancer Cells
The Expression Levels of KAI1 Gene and Its Mechanism in Human Lung Cancer Cell Lines
The Predictive Values of Expression Level of WIF-1, Gsk-3B and Nm23-H1 in the Patients with Non-Small Cell Lung Cancer
Acquired Resistance Mechanisms of Lung Adenocarcinoma to Gefitinib
Influence of Nm23-H1 Gene Site Mutagenesis on Invasive And Metastatic Phenotype in Human High-Metastatic Large Cell Lung Cancer Cell Line L9981
Investigation of the Relationship Between Tyrosine Kinase Receptor Family and Acquired Resistance of Lung Adenocarcinoma to Gefitinib
miR-223 regulates migration and invasion by targeting Artemin in human esophageal carcinoma
miR-610通过调控缝隙连接α3蛋白的表达抑制人肺癌细胞的增殖和侵袭
MiR-132 suppresses the migration and invasion of lung cancer cells via targeting the EMT regulator Z
肺腺癌吉非替尼获得性耐药相关microRNAs的筛选鉴定
期刊信息
  • 《中国肺癌杂志》
  • 中国科技核心期刊
  • 主管单位:中国科学技术协会
  • 主办单位:中国抗癌协会 中国防痨协会 天津医科大学总医院
  • 主编：周清华 郝捷 吴一龙 李为民
  • 地址：天津市和平区南京路228号
  • 邮编：300020
  • 邮箱：cnlungca@gmail.com
  • 电话：022-27219219
  • 国际标准刊号：ISSN：1009-3419
  • 国内统一刊号：ISSN：12-1395/R
  • 邮发代号:6-230
  • 获奖情况:
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,英国农业与生物科学研究中心文摘,波兰哥白尼索引,荷兰文摘与引文数据库,荷兰医学文摘,美国生物医学检索系统,美国剑桥科学文摘,中国中国科技核心期刊,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,瑞典开放获取期刊指南
  • 被引量:12406