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脂肪组织分泌产物及其对脂肪形成的调控
  • 时间:0
  • 分类:Q591[生物学—生物化学]
  • 作者机构:[1]西北民族大学生命科学与工程学院,甘肃兰州730030
  • 相关基金:国家自然科学基金(30671518).
中文摘要:

脂肪组织产生和分泌一系列以自/旁分泌或内分泌方式起作用的细胞因子,参与脂肪组织局部及整个机体能量代谢,并和与肥胖相关的多种代谢综合征有关。阐明脂肪组织分泌因子的生理学作用,有助于更好的理解脂肪形成的机制。本文主要阐述了脂肪组织分泌因子白细胞介素-6、肿瘤坏死因子-α、纤溶酶原激活物抑制因子-1、血管紧张素Ⅱ和抵抗素的功能特性及其对脂肪形成的影响。

英文摘要:

Adipose tissue produces and secretes dozens of factors that participate in energy metabolism of adipose tissue itself and the whole body either in an auto/ paracrine or an endocrine fashion, and that may be involved in obesity - associated metabolic syndrome(MS). Therefore, an elucidation of the physiological role of the factors released from adipose tissue could help to get a better understanding of adipogenesis mechanism. In this paper, the functional characters and effects of some factors secreted from adipose tissue on adipogenesis, such as interleukin -6, tumor necrosis factor - a, plasminogen activator inhibitor - 1, angiotensin Ⅱ and resistin, are elucidated.

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