脂肪组织产生和分泌一系列以自/旁分泌或内分泌方式起作用的细胞因子,参与脂肪组织局部及整个机体能量代谢,并和与肥胖相关的多种代谢综合征有关。阐明脂肪组织分泌因子的生理学作用,有助于更好的理解脂肪形成的机制。本文主要阐述了脂肪组织分泌因子白细胞介素-6、肿瘤坏死因子-α、纤溶酶原激活物抑制因子-1、血管紧张素Ⅱ和抵抗素的功能特性及其对脂肪形成的影响。
Adipose tissue produces and secretes dozens of factors that participate in energy metabolism of adipose tissue itself and the whole body either in an auto/ paracrine or an endocrine fashion, and that may be involved in obesity - associated metabolic syndrome(MS). Therefore, an elucidation of the physiological role of the factors released from adipose tissue could help to get a better understanding of adipogenesis mechanism. In this paper, the functional characters and effects of some factors secreted from adipose tissue on adipogenesis, such as interleukin -6, tumor necrosis factor - a, plasminogen activator inhibitor - 1, angiotensin Ⅱ and resistin, are elucidated.