中文摘要：

目的 探讨同步间歇指令通气＋压力支持通气（SIMV＋PSV）模式对慢性阻塞性肺疾病（COPD）合并呼吸衰竭患者的临床治疗效果。方法 采用回顾分析的方法,对呼吸内科收治的108例慢性阻塞性肺疾病合并呼吸衰竭患者的病史资料进行分析,按照简单数字表法随机选取54例采用SIMV＋PSV治疗模式（观察组）;另54例采用双水平气道正压通气（BIPAP）治疗模式（对照组）。分析比较两组患者治疗前和治疗后第7天的肺功能、氧代谢、血气分析等指标。结果 治疗前两组患者的肺功能、氧代谢、血气分析等指标之间的差异无统计学意义（P〉0.05）;治疗后第7天对照组肺功能、氧代谢、血气分析等指标的改善程度明显低于观察组,两组间差异有统计学意义（P〈0.05）。观察组有7.4%的患者患有低钠血症,13.0%的患者伴有恶心呕吐现象,9.2%的患者有抽搐症状;对照组有42.6%的患者患有低钠血症,22.1%的患者伴有恶心呕吐现象,24.1%的患者有抽搐症状,两组患者的临床症状具有显著差异（P〈0.05）。观察组患者分别有14.2%,12.7%和5.4%的患者有呼吸困难,意识障碍,长期卧床等不良症状;对照组患者分别有48.5%,38.7%和24.3%的患者有呼吸困难,意识障碍,长期卧床等不良症状,两组患者的生活质量具有显著差异（P〈0.05）。结论 COPD并发呼吸衰竭患者,采用SIMV＋PSV治疗模式,比BiPAP治疗模式更能明显改善肺通气换气功能、增加机体氧供和纠正体内酸碱失衡。

英文摘要：

Objective To analyze the effects of synchronous intermittent mandatory ventilation and pressure sup- port ventilation （SIMV＋PSV） in patients on chronic obstructive pulmonary disease （COPD） combined with respiratory failure. Methods By methods of systematic review analysis, the medical history data of all the patients with chronic ob- structive pulmonary disease with respiratory failure were analyzed by methods of systematic review analysis. 54 cases treated by SIMV＋PSV methods were chosen as observation group. 54 cases treated by BIPAP methods were chosen as the control group. The lung function, oxygen metabolism and blood gas were analyzed. Results Before the treatment, there was no significant difference in the lung function, oxygen metabolism and blood gas analysis between the two groups （P〉0.05）. After seventh days treatment, the improvement of lung function, oxygen metabolism and blood gas analysis in the control group was significantly lower than that in the observation group （P〈0.05）. There were 7.4% of patients with hyponatremia, 13.0% with nausea and vomiting phenomenon and 9.2%of patients with convulsions in observation group and control group 42.6 %with hyponatremia, 22.1% with nausea and vomiting and 24.1% with convulsive symp- toms in control group. The clinical symptoms of the patients in the two groups had significant differences （P〈0.05）. There were 14. 2%, 12.7% and 5.4M with difficulty in breathing, disturbance of consciousness and bedridden and other adverse symptoms in observation group, there were 48.5%, 38.7~ and 24.3% with difficulty in breathing, disturbance of consciousness, bedridden and other adverse symptoms in control group. Conclusion For patients with COPD compli- cated with respiratory failure, SIMV ＋PSV treatment can obviously improve the pulmonary ventilation ventilationfunction, increase the body＇s oxygen supply and correct acid-base imbalance in the body.