中文摘要：

目的：研究组分配伍四逆汤对甲状腺功能减退症并发肾损伤的影响。方法：灌胃0.1%丙基硫氧嘧啶（PTU）溶液法造模,用组分配伍四逆汤高、中、低剂量和优甲乐（阳性对照）对模型动物进行治疗,实验结束后,取血,分离血清,用放免法测定血清T3、T4,用紫外分光光度计法测血清尿素氮（BUN）含量,用酶联免疫吸附法测胱抑素C（CYS-C）含量,解剖取肾脏称量质量并计算其系数,固定肾脏并作HE染色,观察其病理变化。结果：与正常对照组比较,模型组肾脏系数显著降低（P〈0.05）,血清T3、T4水平显著降低（P〈0.05或P〈0.01）,BUN及CYS-C含量显著升高（P〈0.05）;与模型组比较,组分配伍四逆汤高、中剂量组及阳性药组血清T3、T4水平显著升高（P〈0.05）,BUN及CYS-C含量显著降低（P〈0.05）。HE染色结果显示模型组大鼠肾小球萎缩、肾小管上皮细胞变性,各给药组大鼠肾病理变化均较模型组有所减轻。结论：组分配伍四逆汤对甲状腺功能减退症并发肾损伤有一定的治疗作用。

英文摘要：

Objective ：To investigate the protective effect of component compatibility Sini Decoction on hypothyroidism induced re- nal damage in rats. Methods ：The hypothyroidism model were established by 0. 1% propyhhiouracil （PTU） solution 10 mL/kg for consec- utive 15 days. Rats were randomly divided into model group, component compatibility Sini Decoction groups [ CSD 9. 6,4. 8 and 2. 4 g/ （kg · d） ] and positive control group[ Euthyrox 9 μg/（ kg · d） ]. Radioimmunoassay was used to determine the serum T3 and T4 levels; serum BUN content was detected by UV speetrophotometer and ELISA method were used to measure the CYS-C content. The kidney was weighed, and the pathological changes of the renal were detected by HE stain. Results ： Compared with blank control group, kidney weight coefficient, serum T3 and T4 levels in model group were decreased, while serum BUN and CYS-C contents were increased （ P 〈 0. 05 or P 〈 0. 01 ）. Compared with model group, serum T3 and T4 contents were increased and serum BUN and CYS-C contents were de- creased （P 〈 0. 05 ） in Sini Decoction groups [ CSD 9. 6 and 4. 8 g/（ kg · d） ] and positive control group. The HE stain results showed that component compatibility Sini Decoction and Euthyrox could relieve glomerular atrophy and renal tubular epithelial cell injury in rats. Conclusion：Component compatibility Sini Decoction has a curative effect on hypothyroidism induced renal damage in rats.