中文摘要：

目的研究人参皂苷Rg1（ginsenosideRg1）对脂多糖（1ipop01ysaccharide，LPS）诱导的脑损伤急性炎症模型小鼠自主活动的影响。方法小鼠腹腔注射LPS构建脑损伤急性炎症模型。记录各组小鼠的总活动距离和穿格次数。免疫组化法检测Rg1对小鼠额叶皮质中自介素1p（IL-1β）表达的影响。结果与对照组比较，模型组小鼠的总活动距离及穿格次数明显减少，且额叶皮质中IL-1β表达水平增高，差异有统计学意义（P〈0．01）。与模型组相比，Rg1-160mg组（腹腔注射160mg／kgRg1）的总活动距离及穿格次数明显增加（P〈0．05），IL-1β的表达水平降低（P〈0．01）。结论Rg1能够改善脂多糖诱导的脑损伤急性炎症期模型小鼠的自主活动。这可能与其抑制IL-1β的表达有关。

英文摘要：

Objective To investigate the effect of ginsenoside Rg1 on the locomotor activity of mice with lipopo- lysaccharide （LPS） -induced acute inflammation in the brain. Methods A mice model of acute inflammatory in the brain was established through intraperitoneal injection of LPS. The total distance of movement and the number of crossing were recorded. The amount of IL - 1β in the frontal cortex was detected by immunohistochemistry. Results Compared with the control, a significant decreased total distance of movement, the remarkably less number of crossing and increased levels of IL - 1βin the frontal cortex were found in Group LPS （P 〈 0.01 ）. Compared with Group LPS, Group Rg1 - 160 mg showed markedly increases in the total distance of movement and the number of crossing （P 〈 0.05）, and a re- duced level of IL - 1β （P 〈 0.01 ）. Conclusion Rg1 can dramatically improve the locomotor activity in mice with brain acute inflammation induced by LSP, which may be related to inhibition of the expression of IL - 1β.