中文摘要：

目的探讨不同类型糖尿病患者的血清干扰素7诱导蛋白10（IP—10）水平及其意义。方法检测1型糖尿病（T1DM，n=78）、2型糖尿病（T2DM，n=49）和正常对照组（NC，n=33）的IP—10水平。T1DM组根据病情进展分为经典T1DM和成人隐匿性自身免疫糖尿病（LADA）组；又根据胰岛自身抗体IAA阳性与否分为自身免疫性T1DM和特发性T1DM组。T2DM组根据大动脉内中膜厚度IMT分为无动脉粥样硬化AS组和有AS组。Cl／SA检测各组IP-10水平。结果（1）IP-10水平在T1DM、T2DM与NC组之间无统计学差异。（2）胰岛自身抗体阳性的自身免疫性T1DM组IP-10水平高于NC组，差异有统计学意义，而T2DM与NC组无统计学差异；病程不同的T1DM IP-10水平无统计学差异。（3）伴或不伴动脉粥样硬化病变的T2DM亚组IP—10水平无统计学差异。结论自身免疫性1型糖尿病患者IP-10水平升高，可能与其介导Th1型细胞免疫反应有关。

英文摘要：

Objective To investigate the significance of serum IP-10 levels in different types of diabetic patients. Methods Serum IP-10 level in 78 cases with type 1 diabetes, 49 cases with type 2 diabetes and 33 cases of healthy controls was measured with ELISA assays. Type 1 diabetic patients were divided into classic type 1 diabetes （n = 39） and latent autoimmune diabetes in adults （LADA, n = 39） according to their disease process, and they were also divided into autoimmune type 1 diabetes （n= 58） and idiopathic type 1 diabetes （n= 20）. Type 2 diabetic patients,according to carotid intima-media thickness （IMT）, were divided into patients with （n=24） or without atherosclerosis （n=25）. Results 1） Serum IP-10 levels were not statistically different among type 1 diabetes,type 2 diabetes and healthy controls. 2） Serum IP-10 concentrations in autoimmune type 1 diabetes with positive islet autoantibody were higher than those in healthy controls（184.96 4-104.48pg/ml vs 146.10 4- 74.61pg/ml, P = 0. 03）; while there were no difference in type 1 diabetes with variable disease durations. 3） No difference in IP-10 levels was found between type 2 patients with（173.54-69.6pg/ml） and without atherosclerosis （188.54-79.7 pg/ml）. Conclusions Serum IP-10 level is augmented in autoimmune type 1 diabetes