中文摘要：

以原代骨髓基质细胞（BMSCs）为模型，在细胞水平上，研究50nlTl氧化铈颗粒对BMSCs的活性、成骨分化和成脂分化的影响．结果表明，氧化铈颗粒促进BMSCs的活性，并呈现很好的剂量及时间依赖性，但其对BMSCs的碱性磷酸酶（ALP）活性、胶原的合成、矿化结节的形成以及成脂分化的影响是复杂的，作用浓度和时间是影响其分化的关键因素．这些实验结果为阐明纳米氧化铈的生物学效应机理及其在生物医学领域的研究应用提供科学依据．

英文摘要：

The effects of cerium oxide nanoparticles （CeO2 NPs） with diameter of 50 nm on the prolif- eration, osteogenic and adipogenic differentation of primary mouse bone mesenchymal stem cells （BMSCs） in vitro were explored. The results showed that CeO2 NIPs promoted the proliferation of BMSCs with close and time dependency. But their effects on alkaline phosphatase （ALP） activity, collagen synthesis, forma- tion of mineralization nodules and adipogenic differentiation were complicated. The concentration and time were key factors. The results provided important scientific basis for explaining their mechanism of biologi- cal effect and application in biomedical fields.