中文摘要：

目的 探讨类风湿关节炎（RA）T淋巴细胞上淋巴细胞激活诱导的受体4—1BB的表达及其作用机制。方法 应用流式细胞术检测30例RA患者和20名正常对照者外周血T细胞活化前后4-1BB的表达。结果RA患者CD4^＋T和CDS^＋T细胞表达的4—1BB明显高于正常对照组[表达百分率分别为（18．56±4．08）％，（10．33±2．13）％，（1．24±0．12）％，（0．87±0．09）％，P＜0．01]，经抗CD3单抗体外刺激后CD4^＋T和CD8^＋T细胞表达的4—1BB均显著高于活化前[表达百分率为（33±4）％和（21±8）％，P＜0．01]。RA患者CD4^＋T／CD8^＋T比值明显升高，而且与4-1BB^＋CD4^＋T细胞数呈正相关关系（r=84，P＜0．01），另外4-1BB^＋CD4^＋T细胞数与血沉、IgA呈正相关关系（r=0．476，P＜0．05；r=0．659，P＜0．05）。结论 RA患者T细胞表达的4-1BB在RA的发生发展中具有重要意义．4-1BB可能通过对CD4^＋T活化与增殖参与关节炎症和免疫反应。

英文摘要：

Objective To investigate the exprdssion and role of costimulatory molecule 4-1BB on T cells of patients with rheumatoid arthritis （RA）. Metheds The expression of 4-1BB on T lymphocytes from 30 RA patients and20 healthy controls were,detected by flow cytometry. Results The expression of 4-1BB on CD4^＋T and CDS^＋T lymphocytees from RA patients was significantly higher than that of normal control （ 18.56±4.08,10.33±13 vs 1.24±0.12, 0.87±0.09, P〈0.01）. There was more expression of 4-1BB on CD4^＋T and CD8^＋T lymphocytes stimulated lay anti-CD3 antibody from RA patients （33±4 vs 21±8, P〈0.01）. In addition, the ratio of CD4^＋T/CD8^＋T in RA patients was higher than that of normal controls and was positively correlated with 4-1BB^＋CD4^＋T cell. The expression of 4-1BB on CD4^＋T in RA patients was positively correlated with the level of ESR and IgA （r=0.476, P〈0.05; r=0.659, P〈0.05）. Conclusion The costimulatory molecule 4-1BB is abnormally expressed in T lymphocytes from patients with rheumatoid arthritis. The abnormal expression of 4-1BB on T lymphocytes may play an important role in the development of RA. The expression of 4-1BB on CD4^＋T cell may take part in the inflammation of RA.