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窄谱中波紫外线联合郁金银屑片治疗寻常型银屑病
  • ISSN号:1673-9701
  • 期刊名称:中国现代医生
  • 时间:2012.3.3
  • 页码:34-36
  • 分类:R758.63[医药卫生—皮肤病学与性病学;医药卫生—临床医学]
  • 作者机构:[1]宁波市医疗中心李惠利医院皮肤科,浙江宁波315040, [2]南京医科大学第一附属医院皮肤科,江苏南京210029
  • 相关基金:国家自然科学基金资助项目(81000700)
  • 相关项目:P53-miRNA23a在中波紫外线辐射后DNA损伤反应中的调控作用及其机制研究
中文摘要:

目的探讨窄谱中波紫外线(NB—UVB)联合郁金银屑片治疗寻常型银屑病的疗效与安全性。方法将人选的96例寻常型银屑病患者随机分为观察组与对照组各48例。对照组予NB—UVB照射治疗,每周3次;观察组在此基础上口服郁金银屑片5片,每日3次。疗程均为8周。观察两组的PASI评分、疗效及不良反应情况。结果治疗4周后.观察组与对照组PASI评分分别为(4.13±2.32)、(6.35±3.14),临床有效率分别为62.5%、39.6%(P〈0.05)。治疗8周后,观察组与对照组PASI评分分别为(2.06±1.20)、(3.58±1.67),临床有效率分别为87.5%、68.8%(P〈0.05)。不同时间点PASI评分进行方差分析显示,差异有统计学意义(P〈0.01)。两组患者不良反应少且轻微。结论NB—UVB联合郁金银屑片治疗寻常型银屑病疗效高,安全性好。

英文摘要:

Objective To investigate the efficacy and safety of yujinyinxie tablet and narrow-band ultraviolet B(NB-UVB) for treatment of psoriasis vulgaris. Methods All of 96 patients with psoriasis vulgaris were randomly divided into observa- tion group and control group with each of 48 cases. The control group were treated with NB-UVB irradiation,3 times/week. On the basis of this, the observation group were treated with yujinyinxie tablets in addition. The course was 8 weeks. PASI score, efficacy and adverse reactions were observed. Results After 4 weeks of treatment, the PASI scores of the observation group and control group were (4.13 ± 2.32) and (6.35 ± 3.14) respectively, and clinical efficacy was 62.5% and 39.6%, respectively (P 〈 0.05). After 8 weeks of treatment, the PASI scores were (2.06 ±1.20) and (3.58±1.67), respectively, and clinical efficacy was 87.5% and 68.8%, respectively (P 〈 0.05). PASI score at different time points were statistically significant by analysis of variance (P 〈 0.01). The adverse reactions in both two groups were few and mild. Conclusion NB-UVB combined with yujinyinxie tablet is effective and safe in the treatment of psoriasis vulgari.

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期刊信息
  • 《中国现代医生》
  • 主管单位:中华人民共和国国家卫生和计划生育委员会
  • 主办单位:中国医学科学院
  • 主编:田玲
  • 地址:北京市朝阳区东四环中路78号楼(大成国际中心B座)708-3室
  • 邮编:100124
  • 邮箱:zgxdys001@vip.163.com
  • 电话:010-59625536
  • 国际标准刊号:ISSN:1673-9701
  • 国内统一刊号:ISSN:11-5603/R
  • 邮发代号:80-611
  • 获奖情况:
  • 国内外数据库收录:
  • 波兰哥白尼索引
  • 被引量:78397