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中文摘要：
目的：观察黄芩苷对UVB照射后小鼠皮肤中光损伤的影响。方法：将黄芩苷外搽于Balb／C小鼠皮肤，检测180mJ／cm2UVB照射后24h小鼠皮肤红斑、水肿、细胞增生、真皮炎症细胞浸润情况。结果：无论是UVB照射前还是照射后外用黄芩苷均明显减轻紫外线照射造成的小鼠皮肤红斑、皮肤水肿，细胞增殖和炎症细胞浸润。结论：黄芩苷可抵抗UVB诱导的小鼠皮肤红斑水肿反应，并通过减少炎症细胞浸润而发挥抗炎作用。
英文摘要：
Objective In this study, we assessed the effects of baicalin on UVB-mediated damages in mice skin. Methods A photodamaged mouse model was established by UVB irradiation. The skin erythema and edema were assessed. HE stain was used for histepathology. Results Our data demonstrated that a topical application of baicalin, either preor post-UVB irradiation, resulted in a significant decrease in UVB-mediated increases in skin edema, skin hyperplasia and infiltration of leukocytes. Conclusion Based on this data, we suggest that baicalin could be developed as an agent for the management of conditions elicited by UV exposure including skin cancer.
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