中文摘要：

为研究关节软骨在滚压载荷下溶质的扩散行为,取成年猪关节软骨,用异硫氰酸荧光素—右旋糖酐标记,分别观察在滚压载荷和静置状态下,软骨中溶质荧光强度随时间和软骨层位置的变化,得到相对浓度和扩散系数的变化规律。结果表明,滚压载荷样本B的溶质相对浓度始终大于静置状态样本A,平均值最大相差62.4%,随时间增加,B组软骨中层和深层相对浓度比A组增加明显;B组扩散系数高于A组,平均值最大相差93%,随时间增加,B组软骨中间层扩散系数比A组显著增加。因此,滚压载荷可以促进关节软骨的溶质传递,提高溶质的扩散系数,特别是对中层和深层影响显著。

英文摘要：

In order to study solute transport behavior of articular cartilage under rolling-compressing load,mature pig articular cartilages were marked by Fluorescein isothiocyanate—Dextran,their solute fluorescence intensity change with time and cartilage depth was observed under rolling-compressing load and static state respectively. The changing laws of relative concentration and diffusivity were obtained. The results showthat solute relative concentration under rollingcompressing load（ sample B） is larger than that under static state（ sample A）,and average maximum is 62. 4% difference. Relative concentration in transitional and deep layers of sample B increases more significantly than that of sample A with time increasing. Diffusivity of sample B is larger than that of sample A,and average maximum is 93% difference. Diffusivity in transitional and deep layer of sample B increases more conspicuously than that of sample A with time increasing. So rolling-compressing load can promote solute transport,and improve solute diffusivity in articular cartilage,especially in transitional and deep layers.