中文摘要：

急性早幼粒细胞白血病（acute promyelocytic leukemia,APL）是急性髓系白血病中的一种特殊类型,以具有t（15;17）染色体易位的细胞遗传学标志和特异性表达早幼粒细胞白血病-维甲酸α受体（PML-RARα）融合蛋白为发病特点。

英文摘要：

The clinical characteristic of acute promyelocytic leukemia （APL） is specific expression of PML- RARα fusion protein. Autophagy pathway plays an important role in PML-RARα fusion protein degradation and differentiation of APL cells. Further study of autophagy pathway in APL contributes to provide a new thought for its clinical treatment. In this article, the constitution of autophagy pathway and its regulation mechanism, PML- RARα fusion protein degradation by autophagy pathway, the role of autophagy in PML-RARα fusion protein UPP- mediated degradation and the role of autophagy-associated drugs in APL are reviewed.