中文摘要：

细胞核重新编程是哺乳动物正常胚胎和克隆胚胎发育的关键性因素，主要表现为表观遗传学上变化。在受精卵形成和发育过程中，基因组的甲基化状态和组蛋白的结合形式均发生改变；在核移植产生的克隆胚胎中，供体细胞核也会经历核膜破裂、早熟染色体凝集等变化，重新获得分化的潜能而发育为正常的克隆动物。同时存在多种因素影响重新编程的进行。现对哺乳动物细胞核重新编程的研究进展进行综述，以期为该领域进一步的探索提供借鉴。

英文摘要：

Nuclear reprogramming is an important event in the mammalian development of normal and cloned embryos. And characteristic changes of nuclear reprogramming are mainly showed in epigenetic marking systems. During the formation and development of zygote, genome undergoes demethylation and acquires histone modifications. In cloned embryo, nuclear envelop breaks down and premature chromosome condensation occurs. Thereafter, the cloned embryo regains development potency to be a cloned animal. There are many factors involved in nuclear reprogramming. This review focuses on current progress of nuclear reprogramming in order to provide the clue for further investigations.