中文摘要：

为了阐明子瘤对于脑动脉瘤破裂风险的血流动力学影响机制,获取带子瘤和未带子瘤的患者CT 图像信 息进行三维重建,得到3D 模型-带子瘤模型和未带子瘤模型2 种 ,通过血流动力学计算方法,利用 Fluent软件 计算并得到计算结果. 分析结果得到两模型各类血流动力学参数-内部流场、壁面切应力（ WSS）、切应力震荡 因子（ OSI）、粒子滞留时间（ RRT ）,并进行比较分析,得到带子瘤模型与未带子瘤模型的结果之间的差异,得出带子 瘤模型对其发展机制的影响. 结果表明：带子瘤的模型内部流场更不稳定,WSS更低（未带子瘤模型W S S最大值为 9. 5 Pa,而带子瘤模型WSS最大值为6 Pa ） ;同时,带子瘤的模型髙OSI的面积大于未带子瘤模型的髙OSI面积;而 带子瘤模型的髙RRT面积也远大于未带子瘤模型的髙RRT面积,说明带子瘤的瘤内部血流方向杂乱,更容易产生 血栓. 因此,带子瘤模型的OSI和 RRT普遍偏髙,而 WS S偏低. 针对带子瘤的模型,内部流场的差异性主要表现 为 ：低 WSS、髙 OSI和髙 RRT,而这三者对动脉瘤的生长发展有很大影响;同时说明WSS、 OSI、R R T是判断动脉瘤破 裂的有效指标,对研究脑动脉瘤的破裂机制具有-定的意义.

英文摘要：

The aim of this study is to elucidate the hemodynamic effects of tumor on the risk of rupture of cerebral aneurysms. A three-dimensional reconstruction of the CT images of the patients with the tumor and the non-band tumor was obtained. 3D model-banded tumor and non-band tumor were obtained. The hemodynamics method was used to calculate and the settlement result was obtained by Fluent software.Wall shear stress （WSS）, shear stress oscillatory factor （OSI）, particle retention time （RRT）, and comparative analysis were carried out to obtain the results of band tumor model and non-band tumor model,and the effect of band tumor model on its development mechanism. The results show that the internal flow field of the model is more unstable,and WSS is lower （the maximum WSS of the non-tumor model is 9. 5 Pa,and the maximal value of WSS is 6 Pa）. At the same time,the model of the band tumor is high and the high RRT area of the band tumor model is much larger than the high RRT area of the non-band tumor model,which indicates that the internal blood flow of the tumor is clutter and is more prone to thrombosis. According to the results,it is concluded that the OSI and RRT of the band tumor model are generally high and the WSS is low, so the conclusion is that the difference of the internal flow field is mainly due to the low WSS, high OSI and the high RRT. The results show that WSS, OSI and RRT are effective indexes to judge the rupture of aneurysm, which is of great significance to the study of the rupture mechanism of cerebral aneurysms.