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Expression of interleukin 6 in brain and colon of rats with TNBS-induced colitis
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  • 分类:R574.62[医药卫生—消化系统;医药卫生—临床医学;医药卫生—内科学]
  • 作者机构:[1]Jilin Univ, Coll Anim Sci & Vet Med, Jilin Prov Key Lab Anim Embryo Engn, Changchun 130062, Jilin Province, Peoples R China, [2]Univ Hebei No, Dept Vet Med, Zhangjiakou 075029, Hebei Province, Peoples R China, [3]Acad Mil Med Sci, Beijing 100071, Peoples R China
  • 相关基金:Supported by The grant from the National Natural Science Foundation of China,No 30871840;No 30901057
  • 相关项目:IL-21在大鼠炎症性肠病中的作用及其中枢机制
中文摘要:

AIM:To characterise expression of interleukin 6(IL-6),a potent proinflammatory cytokine,in the occurrence and development of inflammatory bowel disease(IBD) and investigate its effect on neuroimmunomodulation and immune homeostasis regulation.METHODS:In this study,rats with colitis induced by trinitrobenzene sulfonic acid(TNBS) were sacrificed on days 3,7,14,21 and 28 after induction.In the controls,the TNBS was just replaced by equivalent amount of phosphate buffered solution(PBS,0.01 mol/L).IL-6 mRNA expr...

英文摘要:

AIM:To characterise expression of interleukin 6(IL-6),a potent proinflammatory cytokine,in the occurrence and development of inflammatory bowel disease(IBD) and investigate its effect on neuroimmunomodulation and immune homeostasis regulation.METHODS:In this study,rats with colitis induced by trinitrobenzene sulfonic acid(TNBS) were sacrificed on days 3,7,14,21 and 28 after induction.In the controls,the TNBS was just replaced by equivalent amount of phosphate buffered solution(PBS,0.01 mol/L).IL-6 mRNA expr...

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