中文摘要：

目的：结合白癜风维吾尔医理论与最新疾病机理研究,探讨发生质的变化的六种异常黏液质在外周血及皮损处的IFN-γ、sICAM-1、IgG、Cortisol、5-HT、NE等因子的差异,大样本多角度关联分析白癜风异常黏液质辨证分型与其相关性。方法：采用酶联免疫吸附试验（ELISA）测定450例白癜风患者血清及组织液6种细胞因子：IFN-γ（干扰素-γ）、sICAM-1（可溶性细胞间黏附分子1）、5-HT（五-羟色胺）、Cortisol（皮质醇）、IgG（酪氨酸酶抗体IgG）、NE（去甲肾上腺素）,并与90例健康成人相关指标做对照观察。结果：（1）患者血清IFN-γ、sICAM-1、IgG水平高于健康者,Cortisol水平低于健康者,上述指标的差异有统计学意义;（2）患者血清IFN-γ、Cortisol、IgG、NE水平低于皮损组织液,5-HT水平高于皮损组织液,上述指标的差异有统计学意义;（3）白癜风患者血清六种指标在各分型间无组间差异;（4）皮损组织液IFN-γ、5-HT、IgG水平在各分型间具有显著性差异,其余指标无组间显著性差异。结论：（1）IFN-γ参与局部皮损的发生发展;（2）维吾尔医诊断中不同辨证分型的白癜风在皮损组织液细胞因子水平方面具有差异性,但无法作为一种量化的诊断依据。

英文摘要：

Objective：Combine Uygnr medicine theory of vitiligo and the latest disease mechanism study, to explore the six qualitative change in abnormal ＂Helit＂ ,its possible difference of 6 cytokines（IFN-γ, sICAM-1, IgG, Cortisol ,5-HT, NE）in peripheral blood serum and the skin lesions. With large sample and multi-angle correlation analysis syndrome differentiations with that. Methods：Using ELISA to measure 450 patients＇eytokinges in serum and skin lesion tissue fluid, and also take 90 healthy adults＇related indicators as control observation. Results： （ 1 ） serum IFN-γ, sICAM-1, IgG level higher than the control group, cortisol levels lower than the control group. These cytokines difference was statistically significant （ IFN-γ P 〈 0.05, sICAM-1 P 〈 0.01, IgG P 〈 0.05, Cortisol P 〈 0.01 ） ; （ 2 ） patients serum IFN-γ, Cortisol, IgG, NE levels are lower than those in the skin lesions of tissue fluid, 5-HT levels higher than, these cytokines＇s differences are statistically significant （ IFN-γ P 〈 0.01, Cortisol P 〈 0.01, IgG P 〈 0.01, NE P 〈 0.01,5-HT P 〈 0.01 ） ; （ 3 ） The six cytokines in patiens serum have no significant difference between different syndrome differentiations; （4） IFN-γ,5-HT, the IgG level in patients＇lesions tissue fluid have statistically significant differences between each other （ IFN-γ P 〈 0.05,5-HT P 〈 0.05, IgG P 〈 0.05 ） and other cytokines have no such differences. Conclusion： （1） IFN-γ/involved in the occurrence and development of local lesions; （2） Uygnr medicine＇s diagnosis of vitiligo,which divide vitiligo into different types（ syndrome differentiations）, and these types do have cytokine levels differences in lesions tissue fluid, but can not be used as a quantized diagnostic basis.