中文摘要：

基质细胞衍生因子-1（Stromal cell derived factor-1，SDF-1）是CXC趋化因子家族的重要成员，系统命名为CXCL12，能与它的唯一受体CXC趋化因子受体-4（CXC chemokine receptor-4，CXCR4）形成CXCL12-CXCR4生物学轴，CXCL12-CXCR4生物学轴在肿瘤生长、侵袭、转移过程中发生重要作用。到目前为止，已发现CXCL12-CXCR4在卵巢癌、胰腺癌、肝癌等多种肿瘤组织中表达。然而，国内目前还没有关于CXCL12-CXCR4与卵巢癌关系的相关综述，本文将从趋化因子CXCL12及其受体CXCR4，CXCL12／CXCR4轴与卵巢癌细胞系实验研究，CXCL12-CXCR4轴与卵巢癌的临床研究，CXCL12／CXCR4与卵巢癌预后，CXCL12／CXCR4与卵巢癌治疗展望等五个方面对CXCL12-CXCR4生物轴与卵巢癌的关系，及其在卵巢癌治疗中的应用展开综述。

英文摘要：

SDF-1 （Stromal cell derived factor-1）, system named as CXCL12, is an important member of CXC chemokine family, which could form CXCL12-CXCR4 biological axis with its only receptor CXCR4 （CXC chemokine receptor 4）. CXCL12-CXCR4 biological axis played an important role in tumor growth, invasion and metastasis. So far, it was found that CXCL12-CXCR4 was expressed in various tumor tissues, such as ovarian cancer, pancreatic cancer, and liver cancer. However, there is no domestic reviews on the relationship between CXCL12-CXCR4 and ovarian cancer. In this article, the relationship of CXCL12-CXCR4 biological axis and ovarian cancer, and its application in the treatment of ovarian cancer were reviewed from the following five aspects： CXCL12 and CXCR4; the role of CXCL12/CXCR4 axis in the experimental study of ovarian cancer cell lines; CXCL 12/CXCR4 axis and clinical research on ovarian cancer; role ofCXCL12/CXCR4 in ovarian cancer prognosis; and role of CXCL12/CXCR4 in ovarian cancer treatment.