中文摘要：

生物膜为液晶态磷脂双分子层结构，其中蛋白质镶嵌在生物膜上，处于脂质环境中，因此药物膜的转运、药物接近膜中蛋白质以及随后结合过程等均与药物和生物膜间的相互作用有着密切联系．药物的膜／水分配系数（Km）是评价药物与生物膜间相互作用的定量参数，为药物与生物膜间各种分子作用力的总和，包括静电、氢键和疏水等作用力及立体效应等．

英文摘要：

The thermodynamic partitioning behavior of solutes into immobilized artificial membrane（IAM） and n-octanol/water systems was investigated, including acidic, basic, and amphoteric substances. In an n-octanol/buffer system, partitioning process was entropy-dominated for the most studied drugs, while partitioning of oxolinic and nalidixic acids into n-octanol phase was enthalpy-driven. In IAM chromatography, partitioning into membrane for the studied solutes was enthalpy-driven and an exothermal process. In conclusion, there is a significant difference of solutes＇ partitioning mechanism into either IAM or an n-octanol phase, therefore, presenting the theoretical basis for differing lipophilicity measuring scale.