中文摘要：

DNA 聚合酶贝它(pol ) 的基因在基础切除修理， DNA 复制和 translesion 合成起一个重要作用。这研究试图在食道的癌症调查表示和 DNA pol 的预示的意义。DNA pol 表示用即时量的 PCR (RT-qPCR ) 和从经历了在 2002 和 2006 之间的切除术的 114 个食道的有鳞的癌病人的一个连续系列在织物样品上染色的 immunohistochemical 被分析。Pol 表示在它的关联上被调查到 clinico 病理学的因素和幸存。RT-qPCR 结果比在它的匹配的邻近的非肿瘤织物样品在肿瘤织物显示出 DNA pol mRNA 的更高的表示， DNA pol mRNA 的不同表示有或没有淋巴与在肿瘤之间的意义被注意节点转移。染色结果的 Immunohistochemistry 显示了强壮积极的率是的 pol (51/114 )44.73% 在肿瘤织物取样， 0.00% 在匹配的邻近的非肿瘤织物取样，与重要差别。Kaplan-Meier 幸存曲线揭示了 pol 的那高表情吗？在食道的癌症病人与肿瘤转移和差的预后被联系。我们的数据建议 pol 在肿瘤前进起一个重要作用，那高 pol 表情在食道的有鳞的癌病人预言相反的预后。

英文摘要：

Gene of DNA polymerase beta （polβ） plays an important role in base excision repair, DNA replication and translesion synthesis. This study aims to investigate the expression and prognostic significance of DNA polβ in esophageal cancer. DNA poll expres- sion was analyzed using real-time quantitative PCR （RT-qPCR） and immunohistochemical staining on tissue samples from a consecutive series of 114 esophageal squamous carcinoma patients who underwent resections between 2002 and 2006. Polβ expression was investigated on its correlation to clinico-pathological factors and survival. RT-qPCR results showed higher expres- sion of DNA polβ mRNA in tumor tissue than in its matched adjacent non-tumor tissue sample, different expression of DNA polβ mRNA was noticed with significance between tumors with and without lymph node metastasis. Immunohistochemistry staining results indicated the polβ strong-positive rate was 44.73% （51/114） in tumor tissue samples and 0.00% in matched adjacent non-tumor tissue samples, with significant difference. Kaplan-Meier survival curves revealed that high expression of polβ was associated with tumor metastasis and poor prognosis in esophageal cancer patients. Our data suggests that poll plays an important role in tumor progression and that high polβ expression predicts an unfavorable prognosis in esophageal squamous carcinoma patients.