中文摘要：

低氧诱导因子（hypoxia—inducible factor，HIF）是细胞内感受氧浓度并调节细胞对缺氧产生适应性反应的一种重要的转录因子。HIF是1992年Semenza等在Hep3B细胞中第一次发现的。由于缺氧是很多疾病共同的病理生理基础，如肿瘤、缺血性心脑血管疾病等，因此HIF的发现引起了广泛的关注和深入的研究。在人体所有器官中，脑是对氧浓度变化最敏感的器官，不难推测HIF在神经系统疾病中特别是缺血性脑血管病中可能扮演重要的角色。

英文摘要：

Hypoxia- inducible factor （HIF） is an important transcript factor in sensing the concentration of O2 in cell and regulating the adaptation to hypoxia. HIF is consist of two subunits called α and 13 with α as an oxygen - sensitive unit and 13 as a constitutively expressed unit. The activity of HIF is regulated by both pVHL/proteasomal destruction system and non pVHL/proteasomal destruction system. Because the brain is the most oxygen - sensitive organ, use of HIF may be a potential application in treating cerebral ischemia disease. Yet HIF is reported to have both neuroprotective and proapoptotic functions in cerebral ischemia, which makes the application of HIF more complicated. This review will discuss the possible function and mechanism of HIF in cerebral ischemia, and the possible application of HIF to clinic.