中文摘要：

multicomponent 胺，醛和酉同类的两倍 Mannich 反应被分子的碘高效地催化，以一个 stereoselective 方法生产一系列 4-piperidones。许多胺，醛和酉同类与易变的 functinal 组一起在这个双人脚踏车过程被容忍，包括那些。在 alkyl-imines 和酉同类之间的反应的进一步的调查从胺显示出那 imines，酉同类面对分子的碘在 situ 和 isomerized 被形成到 enamine 加速相应 Mannich 增加。

英文摘要：

A multicomponent double Mannich reaction of amines, aldehydes and ketones was efficiently catalyzed by molecular iodine, producing a series of 4-piperidones in a stereoselective way. A variety of amines, aldehydes and ketones were tolerated in this tandem process, including those with labile functinal groups. Further investigation of the reaction between alkyl-imines and ketones showed that imines from amines and ketones were formed in situ and isomerized to enamine in the presence of molecular iodine to accelerate the corresponding Mannich addition.