中文摘要：

目前,转基因动物技术发展迅速并广泛应用于食品、医药、农业和生物材料等众多领域,带来了巨大的经济效益和社会效益,且发展潜力巨大。同时,转基因动物及其产品的安全性问题也日益突出,表现在转基因动物本身及产品安全性和环境安全性两个主要方面。＂实质等同性原则＂是国际上转基因动物安全性评价的基本原则。从转基因动物及其产品作为食品、药品等的安全性评估;从转基因动物对生态环境安全和影响的评估和非预期效应的评估等三个方面进行了阐述,并对我国转基因动物评价体系的构建提出建议。

英文摘要：

Recent years,transgenic animal technologies have been developed rapidly and been used widely in many fields,such as food,medicine,agriculture and biomaterial.The security issues of transgenic animals and their products on public and environmental safety are increasingly emerged with the enormous economic and social benefits produced.＂Substantial equivalence principle＂ is one of the basic principles in security evaluation of transgenic animals world widely.It elaborates from three aspects,the security assessment of transgenic animals and their products which are as foods and medicines,the assessment of eco-environmental safety and effect of transgenic animals,and the assessment of undesired effects,which are conducive to the establishment of transgenic animals evaluation system in China.