中文摘要：

目的：评价固肾定喘丸对慢性阻塞性肺疾病（COPD）稳定期患者肺功能及生活质量的控制.方法：将94例COPD（肺肾气虚证）稳定期患者随机按数字法分为对照组和观察组各47例.两组均参照“慢性阻塞性肺疾病诊治指南”进行药物与非药物常规治疗.观察组在对照组治疗的基础上加用固肾定喘丸,2g/次,3次/d.疗程均为12周.监测治疗前后肺功能和呼吸肌疲劳指标（MIP）,采用圣乔治呼吸问卷（SGOR）评价生活质量,采用BODE指数评价格疾病严重程度,记录肺肾气虚证治疗前后评分.结果：治疗后对照组用力肺活量（FVC）,一秒用力呼气容积（FEV1）,FEV1/FVC及MIP呈下降趋势,观察则呈上升趋势,并优于对照组（P ＜0.05或P＜0.01）;治疗后观察组呼吸症状、活动能力及疾病影响3个维度和SGOR总评分均低于对照组（P＜0.05）;治疗后观察组FEV1,MMRC,6 min步行试验（6 MWD）及BODE指数总分均低于对照组（P ＜0.05或P＜0.01）;观察组总有效率89.36％优于对照组的57.44％ （P ＜0.01）.结论：固肾定喘丸能改善COPD（肺肾气虚证）稳定期患者肺功能,促进呼吸肌功能的恢复,减轻临床症状,增强患者活力,提高生活质量.

英文摘要：

Objective：To evaluate control of Gushen Dingchuan Pill on pulmonary function and quality of life in patients of stable stage of chronic obstructive pulmonary disease （COPD）.Method：Ninety-four cases of stable stage of COPD with qi deficiency of lung and kidney were randomly allocated into control and experimental groups,47 cases each group.Both groups were treated according to the guideline of COPD diagnosis and therapy.Gushen Dingchuan pills were added into the experimental groups,2 g/time,three times/day.The treatment courses lasted for 12 weeks.Lung function （LF）,respiratory muscle fatigue indicators （MIP）,The st george＇s respiratory questionnaire （SGOR） measuring quality of life,with the index （BODE） on the price of disease severity,record before and after lung and kidney qi deficiency treatment score.Result：Forced expiratory volume in one second,forced expiratory volumeinone second （FEV1） ; forced vital capacity （FVC）,modified Medical research council scale （MMRC）; 6 minutes walk distance （6MWD）; bodynlass index,airflow obstruction,dyspnea,and exercise capacity index,BODE respiratory muscle fatigue indicators （MIP） increased in experimental group while those decreased in control,showing the experimental better than the control （P 〈 =.05 or P 〈0.01）; 3 dimensions including respiratory symptoms,activity and disease impact and the overall scores of SGOR of experimental group were significantly lower than the control （P 〈 O.05） ; FEV1,mMRC,6 MWD and BODE scores of experimental group were lower than those in control （P 〈 0.05 or P 〈 0.01） ; overall effectiveness of the experimental with 89.36% was better than the control with 57.44% （P 〈 0.01）.Conclusion：Gushen Dingchuan pill improved LF,respiratory muscle recovery,clinical symptoms,activity and quality of life of stable stage of COPD with qi deficiency of lung and kidney.