中文摘要：

目的：研究延胡索乙素、延胡索生品和醋炙品提取物在大鼠体内的药动学。方法：高效液相色谱法测定血浆中延胡索乙素的血药浓度，采用3p97药动学处理软件，计算药动学参数，CmaxTmax采用实测值。结果：延胡索乙素单体、延胡索药材生品和醋炙品T1/2为（5．66±1．92）、（4．24±1．54）、（4．35±1．34）h；Tmax为（1．5±0．5）、（1．0±0．55）、（0．5±0．68）h；Cmax为（0．71±0．29）、（0．37±0．11）、（0．67±0．35）μg／ml；AUC0-1为（2．58±0．85）、（1．96±0．69）、（2．95±1．61）μg,／ml。结论：延胡索生品和醋炙品均能缩短延胡索乙素的达峰时间，说明其两者能起效迅速。

英文摘要：

Objective ： To investigate the pharmacokinetics of tetrahydropalmatine monomer and extractive of corydalis and corydalis processed with vinegar in rats. Methods ： The plasma concentrations of tetrahydropalmatine were determined by a reversed phase high performance liquid chromatographic. The plasma concentrations-time data were calculated with 3p97 program. Results ： The main pharmacokinetic parameters of tetrahydropalmatine monomer and extractive of corydalis and corydalis processesd with vinegar as follows ：T1/2 was （5.66±1.92）,（4.24±1.54）,（4.35 ± 1.34） h,Tmax was （1.5 ±0.5）,（1.0 ±0.55）,（0.5 ±0.68） h,Cmax,was （0.71±0. 29）, （0. 37±0. 11 ）, （0.67 ±0. 35 ） μg/ml,AUC0-1, was （2. 58 ±0. 85 ）, （ 1.96 ± 0. 69）, （2.95 ± 1.61 ） μg/mL Conclusion： The T1/2 of corydalis and corydalis processesd with vinegar is more shorter than tetrahydropalmatine monome, the effect of preventing pain is promoted in rats.