中文摘要：

左旋多巴是治疗帕金森病的金标准，但是长期应用后导致运动并发症。近年来研究表明，运动并发症的产生可能与纹状体多巴胺受体长期受到非生理性脉冲样刺激有关，从而提出帕金森病治疗的新理念--连续多巴胺能刺激。改变Ldopa药代动力学特征和给予多巴胺受体激动剂是进行连续多巴胺能刺激的主要手段。连续多巴胺能刺激策略的初步应用显示了良好的临床疗效，但是长期临床疗效仍需要进一步确认。

英文摘要：

Levodopa remains the gold standard for Parkinson＇s disease treatment. Levodopa-induced motor complications are a common source of disability for patients with Parkinson＇s disease. Recently, evidences suggest that motor complications are associated with non-physiological, pulsatile stimulation of striatal dopamine receptors. Thus, a new concept of treating Parkinson＇s disease, the continuous dopaminergic stimulation, is proposed. The main therapeutic strategy of the new concept is just based on optimizing pharmacokinetics of levodopa and application of dopamine receptor agonists. Continuous dopaminergic stimulation has clinically showed a promising effectiveness, but the long term effectiveness should be further confirmed.