中文摘要：

选取20 g健康昆明小鼠14只,随机均分为对照组和处理组,连续21 d分别尾静脉注射生理盐水和0.01 mg/mL地塞米松稀释液,每天一次0.2 mL/次。于第22天对小鼠采血,分析其血细胞密度变化;并迅速处死小鼠,取肝和肾,10%福尔马林固定,石蜡切片、HE染色,显微镜下观察小鼠肝和肾的组织学变化。结果表明,与对照组相比,处理组小鼠血液中的白细胞（WBC）和淋巴细胞（LYM）密度明显降低,肝小叶内和门管区有炎症细胞浸润,肝细胞界限不清,肝索排列松散,肝血窦扩张,肾组织结构无明显变化。说明地塞米松会下调小鼠外周血的免疫力,并对肝有一定的毒副作用。

英文摘要：

Fourteen healthy Kunming mice weighing 20 g were selected and randomly divided into two groups on average and treated with physiological saline and 0.01 mg/mL dexamethasone diluted solution of 0.2 mL/t·d by tail vein injection for 21days.At 22th day,the blood of all the mice was collected to analyze the density of blood cell.The livers and kidneys of rapidly killed mice were taken out and fixed in 10% formalin for paraffin sections and observation under microscope after stained by hematoxylin eosin.The results showed that compared with the control group,the density of white blood cell and lymphocyte in treated mice was decreased obviously.Inflammatory infiltration was observed frequently in hepatic lobules and portal area.The boundary of hepatocytes became indefinite.Hepatic cords were arranged loosely.Hepatic sinusoid was enlarged while the tissue structure of kidney showed no significant difference.It is indicated that Dexamethasone could downregulate the peripheral blood immunity and had certain side effects on the mice liver.