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Prognostic factors influencing clinical outcomes of glioblastoma multiforme
  • 期刊名称:Chin Med J (Engl)
  • 时间:0
  • 页码:1245-1249
  • 语言:英文
  • 分类:TP391.41[自动化与计算机技术—计算机应用技术;自动化与计算机技术—计算机科学与技术] TH774[机械工程—仪器科学与技术;机械工程—精密仪器及机械]
  • 作者机构:[1]Cancer Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China, [2]:Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China, [3]College of Public Health, Peking University, Beijing 100871, China, [4]Department of Radiotherapy, Beijing Tiantan Hospital, Beijing 100050, China, [5]Department of Radiology, Beijing Tiantan Hospital, Beijing 100050, China
  • 相关基金:Acknowledgements This work was supported by a grant from the Chinese National Key Project of Science (No. 30772238).
  • 相关项目:解析GBM基于EGFR/PI3K信号通路多模式靶向治疗靶标的研究
中文摘要:

<正>Objective To identify the correlation between magnetic resonance manifestation and survival of patients with glioblastoma multiforme(GBM). Methods The magnetic resonance imaging(MRI) images of 30 glioblastoma patients were collected.Imaging features including degrees of contrasted area,edema surrounding the tumor,and intensity in T2-weighted imaging were selected to determine their correlation with patient survival.The relationship between imaging and survival time was studied using SPSS 19.0 software.KaplanMeier survival analysis and log-rank test were used to compare the survival curves. Results Patients with <5%contrasted enhancement area of tumor had longer overall survival(OS) than those with >5%contrasted enhancement area of tumor.Patients without edema surrounding the tumor had longer OS than those with edema.Patients with tumor of hyperintensity and/or isointensity in T2-weighted imaging had longer OS than those with hyperintensity and/or isointensity and hypointensity. Conclusions Some MR imaging features including degrees of contrasted area,edema surrounding the tumor,and intensity in T2- weighted imaging are correlated with the survival of patients with GBM.These features can serve as prognostic indicators for GBM patients.

英文摘要:

Objective To identify the correlation between magnetic resonance manifestation and survival of patients with glioblastoma lnultiforme (GBM), Methods The magnetic resonance imaging (MRI) images of 30 glioblastoma patients were collected. Imaging features including degrees of contrasted area, edema surrounding the tumor; and intensity in T2-weighted imaging were selected to determine their correlation with patient survival. The relationship between imaging and survival time was studied using SPSS 19.0 software. Kaplan- Meier survival analysis and log-rank test were used to compare the survival curves. Results Patients with 〈5% contrasted enhancement area of tumor had longer overall survival (OS) than those with 〉5% contrasted enhancement area of tumor. Patients without edema surrounding the tumor had longer OS than those with edema. Patients with tumor of hyperintensity and/or isointensity in T2-weighted imaging had longer OS than those with hyperintensity and/or isointensity and hypointensity. Conclusions Some MR imaging features including degrees of contrasted area, edema surrounding the tumor, and intensity in T2- weighted imaging are correlated with the survival of patients with GBM. These features can serve as prognostic indicators for GBM patients.

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