中文摘要：

目的：观察C57BL／6小鼠感染新生隐球菌后对大脑皮质BDNF和bFGF表达的影响，并探讨BDNF和bFGF在新生隐球菌感染过程中的作用及其意义。方法：48只C57BL／6雌性小鼠随机分为对照组、环磷酰胺组和试验组，免疫组化法检测大脑皮质BDNF和bFGF的表达。结果：尾静脉注入新生隐球菌后6h大脑皮质查见新生隐球菌，2h大脑皮质BDNF的表达明显高于对照组和环磷酰胺组（P〈0．01），0.5h大脑皮质bFGF的表达明显高于对照组和环磷酰胺组（P〈0.01）。结论：新生隐球菌感染后大脑皮质BDNF和bFGF表达增高，提示BDNF和bFGF对新生隐球菌性脑膜炎具有修复作用，有望成为潜在的防治新生隐球菌性脑膜炎的药物。

英文摘要：

Objective： To observe the effect on the expression of BDNF and bFGF in cerebral cortex of C57BL/6 mice infected with Cryptococcus neoformans. Methods： Forty- eight C57BL/6 female mice were randomly divided into experiment group （received 10^6 cells of C. neoformans via the tail vein）, CTX group and controls. The expres- sion of BDNF and bFGF was detected by immunohistochemical technique. Results： Lots of C. neoformans were observed in cerebral cortex of experiment groups after 6 h. After 2 hours, the expression of BDNF in cerebral cortex of experiment group was significantly higher than control group and CTX group （ P 〈0.01）. After 0.5 hours, the expression of bFGF in cerebral cortex of experiment group was significantly higher than control group and CTX group （P 〈 0.01）. Conclusion： BDNF and bFGF may play a positive role in repairmen of cryptococcal meningitis and is potential to be used for the treatment of cryptococcal meningitis.