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中文摘要：
目的：观察卡巴胆碱是否对小胶质细胞增殖产生影响。方法：培养的小胶质细胞系，加入不同浓度的卡巴胆碱或卡巴胆碱与粒细胞巨噬细胞集落刺激因子（Granulocyte-Macrophage Colony-Stimulating Factor, GM-CSF），用MTT方法检测细胞活性，观察对小胶质细胞数量的影响。结果：我们在培养的小胶质细胞系发现，卡巴胆碱显著减少小胶质细胞的数量，并能有效抑制粒细胞巨噬细胞集落刺激因子诱导的小胶质细胞数量增多，并存在剂量依赖效应，10μM浓度效果最为显著。结论：卡巴胆碱可抑制小胶质细胞炎性反应。
英文摘要：
Objectiver： To observe whether carbachol could be effective on the number of microglia. Methods： The number of microglia treated with different doses of carbachol and GM-CSF was determined by MTT assay. Results： We found that carbachol decreased the number of microglia even in the presence of GM-CSF in dose-dependent manner, with the most effective concentration of 10μM. Conclusions： Carbachol could inhibit microglial inflammation.
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