中文摘要：

甲状腺 peroxidase (TPO ) 是涉及甲状腺荷尔蒙合成的关键酶。在 TPO 基因的几个变化可以影响哺乳动物的正常生长和发展。在这研究， TPO 基因被印射，它的表示水平为 Jinhua 猪在在 1 ， 20 ， 45 ， 60 ， 90 ， 120 和 150 天岁时宏大的甲状腺被决定，其他的拼接形式被寻找并且单个核苷酸多型性( SNP ， A/G642 ) TPO ，基因被分析。结果证明猪的 TPO 被印射到 3q22-27， TPO 的表达式水平在猪的 TPO 在各种各样的年龄和二新奇抄本变体之中是相对稳定的基因被发现：拼接的变体 TPO-2 缺乏 exon 8 当 TPO-3 缺乏 exon 时 8 并且 exon 14， 15， 16。而且，我们发现在 TPO 基因的第十四 exon 的 A/G642 的 SNP 显著地与火腿重量被联系(P < 0.05 ) 。我们的结果在动物在甲状腺腺的规定和新陈代谢上提供了重要基础。

英文摘要：

Thyroid peroxidase （TPO） is the key enzyme involved in thyroid hormone synthesis. Several mutations in the TPO gene may affect the normal growth and development of mammals. In this study, the TPO gene was mapped, its expression level was determined in thyroid grand at the age of 1, 20, 45, 60, 90, 120 and 150 days for Jinhua pig, the alternative splicing form was searched and the single nucleotide polymorphism （SNP, A/G642） of TPO gene was analyzed. The results showed that the porcine TPO was mapped to 3q22-27, the expres- sion level of TPO was relatively stable among the various ages and two novel transcript variants in porcine TPO gene were found： the splicing variant TPO-2 lacked exon 8, while TPO-3 lacked exon 8 and exon 14, 15, 16. Moreover, we found that the SNP of A/G642in the fourteenth exon of TPO gene was significantly associated with ham weight （P 〈 0.05）. Our results provided important basis on the regulation and metabolism of the thyroid gland in animals.